The Role of Immature and Mature Adipocytes in Hair Cycling
February 2019
in “Trends in Endocrinology and Metabolism”
TLDR Both immature and mature fat cells are important for hair growth cycles, with immature cells promoting growth and mature cells possibly inhibiting it.
The 2019 review discusses the critical role of both immature and mature adipocytes in the hair follicle (HF) cycle, emphasizing their interaction with HFs within the dermal white adipose tissue (dWAT). It suggests that the balance between these adipocytes is essential for proper HF cycling, with mature adipocytes potentially inhibiting HF progression and immature adipocytes promoting the transition from telogen to anagen phase. The study also explores the mechanisms of interaction, such as the exchange of extracellular vesicles and the influence of light irradiation on adipocyte behavior, which can affect the HF cycle. Additionally, the review indicates that the ratio of immature-to-mature adipocytes and their content can be selectively modified, potentially offering a target for modulating hair growth and photoepilation strategies. The document does not mention a study population, focusing instead on cellular and molecular interactions.
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