TLDR Unique fat cells near fibrotic areas contribute to systemic sclerosis progression.
Adipocytes in the interfacial white adipose tissue (WAT) adjacent to fibrotic lesions in systemic sclerosis (SSc) exhibited unique phenotypes and properties that contributed to fibrotic pathology. These adipocytes, distinct from bulk adipocytes, played a role in the pathogenesis of SSc by differentiating into various fibroblast-like cells. The local ratio of immature to mature adipocytes in this interfacial WAT was particularly significant in the development of SSc, highlighting their involvement in the disease's progression.
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