The FRZB Gene Regulates Hair Follicle Development in Rabbits via the Wnt/β-Catenin Signaling Pathway

    September 2023 in “ World Rabbit Science ”
    Fan Wang, Xiyu Zhang, Yingying Dai … Yang Chen
    Studysummary In this study using Angora rabbits, researchers found that the FRZB gene inhibits hair follicle development by modulating the Wnt/β-catenin signaling pathway, affecting the expression of various genes related to this pathway and altering cell proliferation and apoptosis.
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    Research cited in this study 8

    1. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020
    2. MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2 Journal of cellular physiology · 2019
    3. Gene Expression Profiling Analysis Reveals Fur Development in Rex Rabbits (Oryctolagus Cuniculus) Genome · 2017
    4. Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation Annals of Dermatology · 2014
    5. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    6. Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands Journal of biological chemistry/˜The œJournal of biological chemistry · 2011
    7. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    8. 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism · 2000

    Related research 2

    1. LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells Frontiers in Genetics · 2020
    2. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010