T Helper Type 2 Immune Response in Alopecia Areata

November 2022 in “ Chinese Journal of Dermatology ”

alopecia areata T helper type 2 Th2 immune response dust mite allergy desensitization IgE dupilumab interleukin-4 IL-4 diphenylcyclopropenone Th1 response Th2 Th1

Studysummary This review discusses the relationship between allergies and alopecia areata, highlighting potential roles for anti-allergy and desensitization therapies, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study explored the role of T helper type 2 (Th2) immune response in alopecia areata (AA), a condition characterized by inflammatory and non-scarring hair loss. It was found that allergies, particularly to dust mites, might contribute to severe and recurrent cases of AA, especially in children, due to a predominant Th2 response. Desensitization therapy could suppress this response, potentially reducing the severity of AA relapses. High levels of immunoglobulin E (IgE) were associated with better outcomes from dupilumab treatment, while high interleukin-4 levels indicated poor response to diphenylcyclopropenone immunotherapy. The study suggested that serum IgE, dust mite-specific IgE, and interleukin-4 could serve as biomarkers for Th2 dominance in AA, providing insights for personalized treatment approaches.

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Research cited in this study

13 / 13 results

research The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications

37 citations , December 2021 in “Cells”

This study found that dysregulation of systemic Th1, Th2, and Th17 cytokines is associated with alopecia areata, with specific cytokines linked to disease activity and treatment response.

research Time to Loss of Response for Dupilumab in Ophiasis-Pattern Alopecia Areata

2 citations , September 2021 in “JAAD case reports”

This report describes a case of a woman with ophiasis-pattern alopecia areata who experienced significant hair regrowth and maintained it for 6 months after treatment with dupilumab, though she eventually relapsed.

research Evaluation of the Level of Serum Interleukins (IL-2, IL-4, IL-15, and IL-17) and Its Relationship with Disease Severity in Patients with Alopecia Areata

14 citations , July 2021 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

This study found that alopecia areata patients had higher baseline interleukin levels, which significantly decreased with tofacitinib treatment, though this change did not correspond to disease severity improvement.

research Alopecia Areata-Like and Psoriasis After Dupilumab Use for Atopic Dermatitis

15 citations , July 2021 in “Anais Brasileiros de Dermatologia”

This report describes a rare case of alopecia areata-like psoriasis, associated with skin lesions, following the use of dupilumab in a patient with atopic dermatitis.

research Immunological Properties of Atopic Dermatitis-Associated Alopecia Areata

57 citations , March 2021 in “International Journal of Molecular Sciences”

This study found that type 2 immunity may play a role in the development of alopecia areata in patients with extrinsic atopic dermatitis, indicating different immunological states compared to non-atopic patients.

research Dupilumab Therapy for Alopecia Areata in Pediatric Patients with Concomitant Atopic Dermatitis

19 citations , January 2021 in “Journal of the American Academy of Dermatology”

This study reported that some pediatric patients with alopecia areata experienced hair regrowth with dupilumab treatment, particularly those with concomitant atopic dermatitis, suggesting dupilumab may be beneficial when traditional therapies fail.

research A Potential Role for IL-4 and IL-13 in an Alopecia Areata–Like Phenotype: A Clinical Perspective

4 citations , October 2020 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study suggests that IL-4 and IL-13 may play a role in the immunopathogenesis of alopecia areata in some patients, indicating a possible Th2-driven pathway in this condition.

research Frontiers in Alopecia Areata Pathobiology Research

55 citations , October 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This review discusses emerging research areas in alopecia areata pathobiology, highlighting the potential roles of unconventional immune cells and the need for more targeted therapeutic strategies, but reports no new experimental results.

research Experimental Evaluation of Ebastine, a Second-Generation Antihistamine, as a Supportive Medication for Alopecia Areata

35 citations , March 2010 in “Journal of Dermatological Science”

Ebastine may help regrow hair in alopecia areata patients.