Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy

    April 2026 in “ ACS Applied Materials & Interfaces ”
    Di Feng, Y M Hu, Zhen Zhang … Xinjing Tang
    Studysummary In this study, Sper-12/siRNA nanoparticles effectively suppressed abnormal AR protein levels, promoted hair follicle proliferation, and alleviated hair loss symptoms in androgenetic alopecia model mice, providing a promising delivery platform for siRNA-based therapeutics.
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    Research cited in this study 13

    1. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    2. Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy International Journal of Molecular Sciences · 2024
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    4. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    5. Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia Scientific Reports · 2022
    6. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
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    8. Study of the International Epidemiology of Androgenetic Alopecia in Young Caucasian Men Using Photographs from the Internet Indian Journal of Dermatology · 2015
    9. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    10. Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia American Journal of Human Genetics · 2005
    11. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    12. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    13. The Biology of Hair Follicles The New England Journal of Medicine · 1999