A Cationic Ionic Liquid-Liposome Nanoplatform Enables Transdermal AsiRNA Delivery for Androgen-Dependent Dermatoses

    August 2026 in “ ACS Applied Materials & Interfaces ”
    Zhou Mingqing, Yixuan Tang, Haowei Chen … Jiaheng Zhang
    Studysummary This study reports that a hybrid nanoplatform using ionic liquid liposomes achieved significant reductions in hair loss, inflammatory acne, and skin sebum levels in preliminary human testing by enhancing delivery of siRNA targeting the androgen receptor.
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    Research cited in this study 14

    1. Development and Validation of a Comprehensive In Vitro Organ Model for Androgenetic Alopecia BMC Biotechnology · 2026
    2. Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy ACS Applied Materials & Interfaces · 2026
    3. Compound Platycladus Orientalis Tincture Promotes Hair Regrowth and Is Associated with Hair-Cycle Progression and Wnt/β-Catenin-Related Signaling Journal of Ethnopharmacology · 2026
    4. Nanotechnology-Based Drug Formulation and Delivery Systems for Skin Medical Aesthetic Dermatology: Mechanisms, Applications, and Safety Frontiers in Pharmacology · 2026
    5. Emerging Pharmacotherapies And Regenerative Solutions For Promoting Hair Growth For Androgenetic Alopecia Frontiers in Pharmacology · 2026
    6. Oral Minoxidil Versus Topical Minoxidil for Male Androgenetic Alopecia JAMA dermatology · 2024
    7. Dihydrotestosterone Induces Arterial Stiffening in Female Mice Biology of sex differences · 2024
    8. New Target for Minoxidil in the Treatment of Androgenetic Alopecia Drug Design Development and Therapy · 2023
    9. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    10. Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options Expert Opinion on Therapeutic Targets · 2019
    11. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    12. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    13. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    14. Topically Applied Minoxidil May Cause Fetal Malformation: A Case Report Teratology · 2003