Scalp Microbiome in Male Androgenetic Alopecia: 16S rRNA Sequencing-Based Clinical Characterization, Mouse Model Validation, and Effects on Hair Follicle Cells

    July 2026 in “ Frontiers in Cellular and Infection Microbiology ”
    Li Zhang, Menghui Qin, Danyu Li … Mengru Pang
    Studysummary This study found that patients with androgenetic alopecia had increased scalp microbial diversity and reduced Staphylococcus abundance, particularly in the frontal and vertex regions, suggesting this dysbiosis as a sensitive indicator of AGA.
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    Research cited in this study 12

    1. The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review Clinical, Cosmetic and Investigational Dermatology · 2023
    2. Commensal Microbiome Promotes Hair Follicle Regeneration by Inducing Keratinocyte HIF-1α Signaling and Glutamine Metabolism Science Advances · 2023
    3. The Psychological Consequences of Androgenetic Alopecia: A Systematic Review Journal of Cosmetic Dermatology · 2022
    4. The Inflammatory Component of Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    5. Perifollicular Inflammation and Follicular Spongiosis in Androgenetic Alopecia Journal of The American Academy of Dermatology · 2021
    6. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    7. Comparison of Healthy and Dandruff Scalp Microbiome Reveals the Role of Commensals in Scalp Health Frontiers in cellular and infection microbiology · 2018
    8. Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris Microbiome · 2018
    9. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    10. Eleven Pairs of Japanese Male Twins Suggest the Role of Epigenetic Differences in Androgenetic Alopecia European Journal of Dermatology · 2013
    11. Minoxidil Use in Dermatology, Side Effects, and Recent Patents Recent Patents on Inflammation & Allergy Drug Discovery · 2012
    12. Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Results of a Prospective, Multicenter Study Annals of Dermatology · 2012