Progesterone-Independent Neurosteroid Regulation of Alpha2-GABA-A Receptors in the Hippocampus Subfields

    March 2017 in “ Brain research ”
    Doodipala Samba Reddy, Omkaram Gangisetty, Xin Wu
    Studysummary This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.
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    Research cited in this study 5

    1. A Mouse Kindling Model of Perimenstrual Catamenial Epilepsy Journal of Pharmacology and Experimental Therapeutics · 2012
    2. Neurosteroid Synthesis-Mediated Regulation of GABA A Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007
    3. Changes In Expression Of The Delta Subunit Of The GABA A Receptor And In Receptor Function Induced By Progesterone Exposure And Withdrawal Journal of Neurochemistry · 2006
    4. Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice Neuropharmacology · 2004
    5. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004