Ovarian Cycle-Related Neurosteroid Regulation of GABA-A Receptor Subunit Plasticity in the Hippocampus Subfields

    April 2011 in “ The FASEB Journal ”
    Omkaram Gangisetty, Doodipala Samba Reddy
    TLDR Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.
    The study investigated the role of progesterone (P) in epilepsy by examining GABA-A receptor subunit plasticity in the hippocampus during different stages of the ovarian cycle. It was found that the δ-subunit of the GABA-A receptor was significantly increased in the dentate gyrus (DG) during the diestrous stage compared to the estrous stage, while no changes were observed in the CA1 or CA3 regions. The increase in δ-subunit was not affected by ovariectomy, indicating the influence of the ovarian cycle. The upregulation of the δ-subunit was not diminished in progesterone receptor knockout mice but was reduced in mice treated with finasteride, suggesting that ovarian P-derived neurosteroids regulate GABA-A δ subunit expression, influencing tonic inhibition and catamenial epilepsy.
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