Sustained Exosome-Guided Macrophage Polarization Using Hydrolytically Degradable PEG Hydrogels for Cutaneous Wound Healing: Identification of Key Proteins and miRNAs, and Sustained Release Formulation

March 2022 in “ Small ”

Gijung Kwak, Jing Cheng, Hyo‐Suk Kim, Sukyung Song, Su Jin Lee, Yoosoo Yang, Ji Hoon Jeong, Ji Eun Lee, Phillip B. Messersmith, Sun Hwa Kim

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exosomes M2-derived exosomes M1 macrophages M2 macrophages hydrogel system wound healing protein signatures miRNA signatures proteomic sequencing genomic sequencing M2-Exo-loaded hydrogel inflammation proliferation cutaneous wound healing M2-Exos hydrogel protein markers miRNA markers proteomic analysis genomic analysis M2-Exo hydrogel healing

Studysummary In an animal model, this study found that PEG hydrogels delivering M2 macrophage-derived exosomes effectively promoted M1 to M2 macrophage transition and enhanced wound healing.

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