G2 Stem Cells Orchestrate Time-Directed, Long-Range Coordination of Calcium Signaling During Skin Epidermal Regeneration

    October 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Jessica L. Moore, Feng Gao, Catherine Matte-Martone … Valentina Greco

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that epidermal stem cells in live mice exhibit coordinated intercellular Ca 2+ signaling governed by G2 cycling stem cells and mediated by Connexin43, essential for tissue-wide communication during regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 7

    1. Skin-Resident Immune Cells Actively Coordinate Their Distribution With Epidermal Cells During Homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2021
    2. Calcium Regulation of Stem Cells EMBO reports · 2020
    3. Lymphatic Vessels Interact Dynamically with the Hair Follicle Stem Cell Niche During Skin Regeneration In Vivo The EMBO Journal · 2019
    4. Intravital Imaging of Hair Follicle Regeneration in the Mouse Nature Protocols · 2015
    5. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    6. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    7. Conditional Expression of the ErbB2 Oncogene Elicits Reversible Hyperplasia in Stratified Epithelia and Up-Regulation of TGFα Expression in Transgenic Mice Oncogene · 1999