Stem Cells and Aberrant Signaling of Molecular Systems in Skin Aging

November 2014 in “ Ageing Research Reviews ”

Yan Peng, Ming Xuan, Victor Leung, Biao Cheng

skin-resident stem/progenitor cells SKPs telomere shortening DNA repair defects oxidative stress genetic changes epigenetic changes skin homeostatic imbalance antioxidants hormone replacement therapy stem cell-based treatments regenerative medicine stem cells HRT

Studysummary This review discusses the mechanisms of skin aging, highlighting the roles of stem/progenitor cells, genetic and environmental factors, and suggests potential for cell-based therapies, but reports no new experimental findings.

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research Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells

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research Telocytes in Human Skin – Are They Involved in Skin Regeneration?

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research The Chemokine SDF-1/CXCL12 Regulates the Migration of Melanocyte Progenitors in Mouse Hair Follicles

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research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

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research Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

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research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

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research Gender Differences in Mouse Skin Morphology and Specific Effects of Sex Steroids and Dehydroepiandrosterone

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The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

research The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

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research Skin Aging and Menopause: Implications for Treatment

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research Hormone Replacement Therapy and the Skin

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