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    The Immune Response to COVID-19: Does Sex Matter?

    April 2022 in “ Immunology ”
    Jim Q. Ho, Mohammad Reza Sepand, Banafsheh Bigdelou … Saeid Zanganeh
    Studysummary This review discusses sex differences in immune responses to COVID-19 and highlights that males tend to experience more severe symptoms and higher mortality but reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. The Immune Response to COVID-19: Does Sex Matter? Immunology · 2022
    2. Female Sex Is a Risk Factor Associated with Long-Term Post-COVID Related Symptoms but Not with COVID-19 Symptoms: The LONG-COVID-EXP-CM Multicenter Study Journal of Clinical Medicine · 2022
    3. Impact of Androgen Deprivation Therapy on Mortality of Prostate Cancer Patients with COVID-19: A Propensity Score-Based Analysis Infectious Agents and Cancer · 2021
    4. Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial Frontiers in Medicine · 2021
    5. The Antiandrogen Enzalutamide Downregulates TMPRSS2 and Reduces Cellular Entry of SARS-CoV-2 in Human Lung Cells Nature Communications · 2021
    6. Post-COVID-19 Syndrome: Persistent Symptoms at the Post-Viral Stage of the Disease. A Systematic Review of Current Data Frontiers in Medicine · 2021
    7. The Double-Edged Sword of Testosterone’s Role in the COVID-19 Pandemic Frontiers in Endocrinology · 2021
    8. Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial Cureus · 2021
    9. Sex Differences in COVID-19: The Role of Androgens in Disease Severity and Progression Endocrine · 2020
    10. The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases Frontiers in immunology · 2020
    11. Racial Variations in COVID-19 Deaths May Be Due to Androgen Receptor Genetic Variants Associated with Prostate Cancer and Androgenetic Alopecia. Are Anti-Androgens a Potential Treatment for COVID-19? Journal of Cosmetic Dermatology · 2020
    12. A Preliminary Observation: Male Pattern Hair Loss Among Hospitalized COVID-19 Patients in Spain – A Potential Clue to the Role of Androgens in COVID-19 Severity Journal of Cosmetic Dermatology · 2020