Platelet-Rich Plasma in Female Androgenic Alopecia: A Comprehensive Systematic Review and Meta-Analysis

May 2021 in “ Frontiers in Pharmacology ”

Shuying Zhou, Fei Qi, Yue Gong, Chen-Xi Zhang, Siqi Zhao, Xutong Yang, Yanling He

platelet-rich plasma female androgenic alopecia hair density placebo adverse effects injection sites randomized controlled trials PRP FPHL

TLDR PRP shows promise for treating female hair loss but needs more research.

The systematic review and meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) in treating female androgenic alopecia (FPHL) and included 42 studies with 1,569 cases, of which 776 were female participants. PRP showed positive responses and improvements in hair density compared to baseline and placebo, with minimal adverse effects such as mild pain and bruising at injection sites. The study concluded that PRP is a promising treatment for FPHL, though further high-quality randomized controlled trials are needed to confirm its efficacy due to considerable heterogeneity and publication bias.

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Research cited in this study

16 / 16 results

research A Systematic Review of the Effect of Platelet-Rich Plasma on Androgenetic Alopecia in Women

11 citations, June 2020 in “Dermatologic Therapy”

PRP treatment improves hair density and diameter in women with androgenetic alopecia.

research Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis

15 citations, May 2020 in “Journal of Dermatological Treatment”

PRP treatment increases hair density and thickness in androgenetic alopecia by 79%.

Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

research Platelet-Rich Plasma and Micrografts Enriched with Autologous Human Follicle Mesenchymal Stem Cells Improve Hair Regrowth in Androgenetic Alopecia: Biomolecular Pathway Analysis and Clinical Evaluation

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PRP and HF-MSCs treatment improves hair growth, thickness, and density in androgenetic alopecia.

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The Trichoscopy Derived Sinclair Scale offers a more accurate and reliable way to measure hair loss severity than the traditional visual method.

research Correlation Between Individual Inflammation Genetic Profile and Platelet-Rich Plasma Efficacy in Hair Follicle Regeneration: A Pilot Study Reveals Prognostic Value of IL-1α Polymorphism

4 citations, November 2017 in “PubMed”

Your genes, especially IL-1a, can predict how well a hair growth treatment with platelet rich plasma will work for you.

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2 citations, April 2017 in “Plastic and Aesthetic Nursing”

Platelet-rich plasma therapy shows promise for hair regrowth in alopecia patients.

research Interventions for Female Pattern Hair Loss

21 citations, May 2016 in “The Cochrane library”

Topical minoxidil helps treat female pattern hair loss, but more research needed for other treatments.

research Evidence-Based Treatments for Female Pattern Hair Loss: A Summary of a Cochrane Systematic Review

40 citations, October 2012 in “British Journal of Dermatology”

Minoxidil helps regrow hair in female pattern hair loss, but more research needed for other treatments.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

research Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities

126 citations, January 2010 in “British Journal of Dermatology”

Baldness is more common in Chinese men than women, increasing with age, and is influenced by genetics.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research Phototrichogram Analysis of Japanese Female Subjects with Chronic Diffuse Hair Loss

25 citations, June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Phototrichogram and hair diameter measurements are effective, noninvasive ways to assess hair growth and detect early hair loss, with the most common pattern being reduced hair density.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations, August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

research Female Pattern Hair Loss

226 citations, September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

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157 citations, July 2001 in “British Journal of Dermatology”

AGA more common in men, Koreans have lower rates and unique patterns.

research The Psychology of Hair Loss and Its Implications for Patient Care

138 citations, March 2001 in “Clinics in Dermatology”

Hair loss can significantly affect a person's self-esteem and body image, especially in young people, those who value their looks highly, and women.

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