In Situ Integration of Porous Polyethylene Nanomembrane with Wound Exudates for Scarless Healing

    November 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Shijie Yuan, Qiao Gu, Xingchen Guo … Ping Gao

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study introduced a novel scarless healing material called pgPE, made from a porous UHMWPE nanomembrane, and found that it promotes complete skin reconstruction and hair follicle regeneration by alleviating hypoxia and modulating immune responses to foster scar-free wound healing.
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    Research cited in this study 9

    1. Sprayable Biomimetic Double Mask With Rapid Autophasing And Hierarchical Programming For Scarless Wound Healing Science Advances · 2024
    2. New Insights Into Balancing Wound Healing And Scarless Skin Repair Journal of Tissue Engineering · 2023
    3. Topological Distribution of Wound Stiffness Modulates Wound-Induced Hair Follicle Neogenesis Pharmaceutics · 2022
    4. Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing Nature Materials · 2020
    5. Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges Journal of Translational Medicine · 2020
    6. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    7. M2 Macrophages Promote Wound-Induced Hair Neogenesis Journal of Dermatological Science · 2018
    8. Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis Regeneration · 2015
    9. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015