Pharmacokinetics and Safety of 1 mg Oral Minoxidil Tablets in Healthy Female Volunteers: A Phase I Randomized Crossover Clinical Trial

    September 2026 in “ JEADV Clinical Practice ”
    Dolores Ochoa Mazarro, Ignacio Galicia, Ana López-Ballesteros
    Studysummary This study found that a 1 mg oral minoxidil tablet has a consistent pharmacokinetic profile and higher bioavailability compared to a 2% topical solution, with a favorable safety profile.
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    Research cited in this study 10

    1. Clinical Efficacy and Safety of Low-Dose Oral Minoxidil Versus Topical Solution in the Improvement of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    2. Recommendations on the Clinical Management of Androgenetic Alopecia: A Consensus Document from the Spanish Trichology Group of the Spanish Academy of Dermatology and Venereology Actas Dermo-Sifiliográficas · 2023
    3. Comparison of Oral Minoxidil, Finasteride, and Dutasteride for Treating Androgenetic Alopecia Journal of Dermatological Treatment · 2022
    4. Randomized Clinical Trial of Low-Dose Oral Minoxidil for the Treatment of Female Pattern Hair Loss: 0.25 mg Versus 1 mg Journal of The American Academy of Dermatology · 2022
    5. Review of Oral Minoxidil as Treatment of Hair Disorders: In Search of the Perfect Dose 2021
    6. How Safe Is Prescribing Oral Minoxidil in Patients Allergic to Topical Minoxidil? Journal of The American Academy of Dermatology · 2020
    7. Minoxidil 1 mg Oral Versus Minoxidil 5% Topical Solution for the Treatment of Female-Pattern Hair Loss: A Randomized Clinical Trial Journal of The American Academy of Dermatology · 2019
    8. Case Series of Oral Minoxidil for Androgenetic and Traction Alopecia: Tolerability and the Five C’s of Oral Therapy Dermatologic Therapy · 2018
    9. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    10. Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination, and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial Journal of research in pharmacy practice · 2017