Particulate Matter Induces Inflammatory Response in Human Outer Root Sheath Cells via Oxidative Stress-Dependent MAPK and JAK-STAT Signaling Pathways
particulate matter human outer root sheath cells oxidative stress MAPK signaling pathway JAK-STAT signaling pathway reactive oxygen species aryl hydrocarbon receptor p38 JNK STAT3 inflammatory mediators cytokines COX-2 PGE2 IL-1α IL-1β IL-6 IL-8 MMP-1 N-acetyl-L-cysteine hair growth PM ORS cells ROS AhR NAC
TLDR Particulate matter causes inflammation in hair cells, potentially harming hair growth.
This study investigates the impact of particulate matter (PM) on human outer root sheath (ORS) cells, focusing on oxidative stress-dependent MAPK and JAK-STAT signaling pathways. PM exposure increased reactive oxygen species (ROS) generation and activated aryl hydrocarbon receptor (AhR), p38, JNK, and STAT3, leading to elevated levels of inflammatory mediators and cytokines such as COX-2, PGE2, IL-1α, IL-1β, IL-6, IL-8, and MMP-1. Pretreatment with N-acetyl-L-cysteine and inhibitors of MAPK and JAK-STAT pathways reduced these inflammatory responses. The findings suggest that PM-induced inflammation in ORS cells via these pathways could impair hair growth.
