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    ROS-Scavenging Microneedles Loaded with Portulaca Oleracea L.-Derived Exosomes for Atopic Dermatitis Therapy

    October 2025 in “ Nano Research ”
    Bo Zhao, Xinchi Jiang, Wanshu Li … Hangjuan Lin
    Studysummary In this study, researchers developed a dissolvable microneedle patch combining HA-TEMPO and Portulaca oleracea L.-derived nanoparticles, which effectively reduced oxidative stress and inflammation in an atopic dermatitis model while restoring immune balance, suggesting a promising treatment strategy.
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    Research cited in this study 7

    1. A Review on Ethnopharmacology, Phytochemistry, Pharmacology and Potential Uses of Portulaca Oleracea L. Journal of ethnopharmacology · 2023
    2. Protac Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration Small methods · 2022
    3. Dissolving Microneedles: Applications and Growing Therapeutic Potential Journal of Controlled Release · 2022
    4. Advanced Nanocarrier- and Microneedle-Based Transdermal Drug Delivery Strategies for Skin Diseases Treatment Theranostics · 2022
    5. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    6. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    7. Hyaluronic Acid, a Promising Skin Rejuvenating Biomedicine: A Review of Recent Updates and Pre-Clinical and Clinical Investigations on Cosmetic and Nutricosmetic Effects International journal of biological macromolecules · 2018