Preparation of Oxygen-Filled Adipose-Derived Stem Cells Exosome-Nanobubbles Gel for Ultrasound-Assisted Full-Thickness Wound Healing in Rats

    September 2026 in “ Biomedicine & Pharmacotherapy ”
    Elnaz Bagheri, Elahehsadat Aminyazdi, Sara Amel … Mona Alibolandi
    Studysummary This study found that a newly developed ultrasound-responsive hydrogel, incorporating ADSC-derived exosome nanobubbles, substantially improved wound healing in rats by enhancing skin closure, re-epithelialization, and hair follicle regeneration, while potentially reducing scar formation.
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    Research cited in this study 6

    1. RGDSP-Functionalized Peptide Hydrogel Stimulates Growth Factor Secretion Via Integrin αv/PI3K/AKT Axis for Improved Wound Healing by Human Amniotic Mesenchymal Stem Cells Frontiers in Bioengineering and Biotechnology · 2024
    2. Stem Cell-Derived Exosomes: Emerging Therapeutic Opportunities for Wound Healing Stem cell research & therapy · 2023
    3. New Insights Into Balancing Wound Healing And Scarless Skin Repair Journal of Tissue Engineering · 2023
    4. Wound-Induced Hair Neogenesis Model Journal of Investigative Dermatology · 2022
    5. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    6. Through the Lens of Hair Follicle Neogenesis: A New Focus on Mechanisms of Skin Regeneration After Wounding Seminars in Cell & Developmental Biology · 2019