Oral Supplementation with L-Cystine, Serenoa Repens, Cucurbita Pepo, and Pygeum Africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

This study evaluated the efficacy of an oral supplement containing L-Cystine, Serenoa repens, Cucurbita pepo, Pygeum africanum, vitamins, and micronutrients in treating chronic telogen effluvium (CTE) and androgenetic alopecia (AGA). Eighty patients aged 18-60 were randomized to receive either the supplement or a placebo for 6 months. Results showed a significant increase in hair density by 9.9 hairs/cm² after 3 months and 12.3 hairs/cm² after 6 months in the supplement group compared to the placebo group. The supplement also improved overall hair volume and appearance without any moderate or severe adverse events. The study concludes that oral supplementation can effectively enhance hair density, anagen hairs, and overall hair appearance in patients with AGA or CTE.