PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

    June 2006 in “ Journal of Dermatological Science ”
    Yoshihiko Tomita, Masashi Akiyama, Hiroshi Shimizu
    Studysummary This study found that injecting PDGF-AA and -BB into mouse skin immediately triggered the hair growth cycle's anagen phase, suggesting potential treatment options for certain types of alopecia.
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    Research cited in this study 6

    1. Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle Experimental Dermatology · 2003
    2. In Vivo Promoted Growth of Mice Hair Follicles by the Controlled Release of Growth Factors Biomaterials · 2003
    3. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    4. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    5. Local Injection of Hepatocyte Growth Factor/Scatter Factor Alters Cyclic Growth of Murine Hair Follicles Journal of Investigative Dermatology · 1998
    6. Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus Journal of Investigative Dermatology · 1996