41 citations
,
May 2001 in “PubMed” This study proposes a new clinical scoring method for hair density based on hair diameter diversity, which correlates with existing measures and reflects follicle miniaturization in androgenetic alopecia.
51 citations
,
September 2000 in “Acta dermato-venereologica” This study found that PPAR alpha, -delta, and -gamma are expressed in human hair follicle cells, and clofibrate exhibited a beneficial effect on hair follicle survival in culture within a specific concentration range.
86 citations
,
August 2000 in “Pigment cell research” This study observed that melanogenesis in human hair follicles is linked to anagen phases, with melanocyte activity and enzyme expression being region-specific to the nascent bulb.
67 citations
,
July 2000 in “Proceedings of the National Academy of Sciences” This study developed a follicular automaton model that simulates human hair cycle dynamics and can replicate hair pattern changes associated with diffuse or androgenetic alopecia.
28 citations
,
July 2000 in “PubMed” This study found no structural differences between in vitro and in vivo grown hair, with keratinization and organization of keratin being comparable in both settings.
111 citations
,
April 2000 in “British journal of dermatology/British journal of dermatology, Supplement” In this study, physiological levels of free T3 significantly enhanced the survival of human hair follicles in vitro.
77 citations
,
March 2000 in “Journal of Investigative Dermatology” The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.
231 citations
,
December 1999 in “Journal of Investigative Dermatology” This study found that the volume of a hair follicle's dermal papilla is strongly correlated with its size, primarily due to the number of cells it contains and the volume of extracellular matrix.
235 citations
,
July 1999 in “Journal of biological chemistry/The Journal of biological chemistry” This study establishes a catalog of human type I hair keratins and identifies their specific roles and expression patterns during hair differentiation and growth in scalp follicles.
129 citations
,
June 1999 in “Archives of Dermatology” This study found that hair density is significantly lower in African Americans compared to whites, which may affect the evaluation and diagnosis of scalp biopsy specimens in this population.
34 citations
,
September 1997 in “Acta Dermato Venereologica” This study found that RXR agonists stimulated human hair follicle growth and survival in vitro, suggesting potential for promoting hair growth in humans.
57 citations
,
August 1997 in “Microscopy Research and Technique” This review discusses novel molecular techniques in skin appendage research and summarizes the distribution of key molecules, but it reports no new experimental results.
23 citations
,
July 1997 in “British Journal of Dermatology” This study suggests that the inner root sheath plays a significant role in maintaining hair follicle homeostasis during the catagen phase's early stages.
81 citations
,
February 1997 in “Journal of Investigative Dermatology” This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.
122 citations
,
July 1994 in “Journal of Investigative Dermatology”
157 citations
,
April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
125 citations
,
August 1992 in “Development” This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.
745 citations
,
February 1992 in “Trends in genetics” This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
385 citations
,
November 1990 in “Journal of Cell Science” This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.