New Drugs for Alopecias

September 2019

Jacob Griggs, Rodrigo Pirmez, Antonellá Tosti

androgenetic alopecia alopecia areata prostaglandin analogs bimatoprost latanoprost SM04554 finasteride JAK inhibitors tofacitinib ruxolitinib stem cell-based therapies Wnt/β-catenin signaling pathway apremilast Propecia Latisse Xalatan

TLDR New treatments show promise for hair loss, especially JAK inhibitors for alopecia areata.

The document reviewed various treatments for alopecia, focusing on androgenetic alopecia and alopecia areata. It discussed the use of prostaglandin analogs like bimatoprost and latanoprost, which were studied for their potential to promote hair growth. Clinical trials, such as those involving SM04554 and finasteride, were conducted to assess new topical treatments. The role of JAK inhibitors, including tofacitinib and ruxolitinib, was highlighted for their efficacy in treating alopecia areata, with studies involving up to 90 patients. The document also mentioned the exploration of stem cell-based therapies and the modulation of signaling pathways like Wnt/β-catenin. However, some treatments like apremilast showed limited efficacy in certain cases. Overall, the document provided a comprehensive overview of emerging therapies and their potential in treating different forms of alopecia.

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Research cited in this study

28 / 28 results

research New Drugs Under Investigation for the Treatment of Alopecias

26 citations , January 2019 in “Expert Opinion on Investigational Drugs”

New treatments for hair loss show promise, but more research is needed to confirm their safety and effectiveness.

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23 citations , October 2018 in “Expert Opinion on Drug Safety”

Consider benefits and risks of new alopecia treatments for safety.

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39 citations , March 2018 in “Archives of Dermatological Research”

Androgens may block hair growth signals, targeting this could treat hair loss.

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

research An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

130 citations , February 2018 in “Journal of Investigative Dermatology”

Tofacitinib may help treat severe hair loss, but more research is needed.

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53 citations , January 2018 in “JAAD case reports”

Dupilumab for eczema may cause hair loss.

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290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Lack of Efficacy of Apremilast in 9 Patients with Severe Alopecia Areata

23 citations , September 2017 in “Journal of the American Academy of Dermatology”

Apremilast did not work for treating severe alopecia areata.

research Conventional and Novel Stem Cell-Based Therapies for Androgenic Alopecia

22 citations , August 2017 in “Stem cells and cloning”

Stem cell technologies and regenerative medicine, including platelet-rich plasma, show promise for hair restoration in treating hair loss, but more research is needed.

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77 citations , June 2017 in “Advances in Therapy”

New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.

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83 citations , June 2017 in “Journal of the American Academy of Dermatology”

Topical JAK inhibitors may help children with alopecia areata regrow hair.

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Male pattern baldness involves genetics, hormones, and needs better treatments.

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JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

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238 citations , November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

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222 citations , September 2016 in “JCI insight”

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

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196 citations , September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

research Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

42 citations , December 2015 in “International Journal of Clinical Pharmacology and Therapeutics”

The 0.25% finasteride solution, when applied once a day, effectively reduces scalp DHT, potentially minimizing sexual side-effects linked to a systemic DHT reduction.

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27 citations , December 2015 in “Clinical and Experimental Dermatology”

Diphencyprone helped most patients with alopecia areata regrow some hair.

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12 citations , November 2015 in “Journal of Investigative Dermatology Symposium Proceedings”

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Blocking JAK-STAT signaling can lead to hair growth.

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52 citations , December 2014 in “Journal of Dermatological Science”

Apremilast may help treat hair loss in alopecia areata.

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Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

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Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

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421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

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PGD2 stops hair growth and is higher in bald men with AGA.

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Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

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Latanoprost 0.1% may effectively treat hair loss.

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69 citations , April 2010 in “Clinical ophthalmology”

Bimatoprost is effective for growing longer, thicker, and darker eyelashes.

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162 citations , August 2002 in “Survey of Ophthalmology”

Latanoprost can make eyelashes longer, thicker, and darker.

Related Research

9 / 9 results

Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study

research Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study

March 2023 in “International Journal of Trichology”

Using both minoxidil and finasteride together is more effective for male hair loss than using either one alone.

research Simultaneous Quantification of Minoxidil and Finasteride in Bulk and Pharmaceutical Dosage Form by RP-HPLC Method

February 2021 in “European Chemical Bulletin”

A reliable method was developed to measure Minoxidil and Finasteride accurately in medicines.

research Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride

13 citations , September 2018 in “Dermatologic Therapy”

Finasteride effectively stops hair loss in most patients, but concerns about rare sexual side effects exist.

A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

research A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia

43 citations , July 2018 in “Journal of The European Academy of Dermatology and Venereology”

Finasteride and minoxidil mix works better for hair growth than minoxidil alone, with similar safety.

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

54 citations , May 2018 in “Journal of The European Academy of Dermatology and Venereology”

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

research The Modern Treatment of Androgenetic Alopecia

February 2017 in “Vestnik dermatologii i venerologii”

Hair loss can be treated with common methods like minoxidil and finasteride, but new potential treatments include growth factors, cytokines, and platelet-rich plasma injections.

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August 2016 in “International journal of scientific research”

Using minoxidil with finasteride in a cream helps maintain hair thickness after stopping oral finasteride.

Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients

research Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients

32 citations , June 2015 in “Dermatologic Therapy”

Finasteride and minoxidil together work best for male hair loss.

research A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia

5 citations , January 2015 in “Journal of clinical & experimental dermatology research”

MorrF improves hair growth better than minoxidil alone.