Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

    Roberto Cosimo Melcangi, Daniele Santi, Roberto Spezzano … Guido Cavaletti
    Studysummary This study found that patients with post-finasteride syndrome exhibited major depressive disorder, severe erectile dysfunction, and neuropathy, alongside altered neuroactive steroid levels in cerebrospinal fluid.
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    Research cited in this study 29

    1. Exploring the Neural Mechanisms of Finasteride: A Proteomic Analysis in the Nucleus Accumbens Psychoneuroendocrinology · 2016
    2. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    3. Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain Journal of Dermatological Treatment · 2016
    4. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    5. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    6. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    7. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    8. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    9. Adverse Event Reporting in Clinical Trials of Finasteride for Androgenic Alopecia: A Meta-Analysis PubMed · 2015
    10. New Steps Forward in the Neuroactive Steroid Field The Journal of Steroid Biochemistry and Molecular Biology · 2015
    11. On the Effects of Testosterone on Brain Behavioral Functions Frontiers in Neuroscience · 2015
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    13. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    14. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    15. Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology The Journal of Sexual Medicine · 2013
    16. Effects of 5-Alpha Reductase Inhibitors on Erectile Function, Sexual Desire, and Ejaculation Expert Opinion on Drug Safety · 2012
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    20. Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012
    21. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    22. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    23. SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder Cell · 2010
    24. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    25. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    26. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    27. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
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    Related research 1

    1. The Influence of Low Dose Finasteride, a Type II 5α-Reductase Inhibitor, on Circulating Neuroactive Steroids Hormone Molecular Biology and Clinical Investigation · 2009