Polycystic Ovary Syndrome: Challenges in Adolescence

June 2010 in “ Endocrinología y Nutrición ”

Ana Oliveira, Bernarda Sampaio, Ana Teixeira, Cíntia Castro-Correia, Manuel Fontoura, José Luis Valdez Medina

polycystic ovary syndrome PCOS anovulation androgen excess obesity insulin resistance diabetes metabolic syndrome plasma total testosterone hirsutism pelvic ultrasound oral contraceptives anti-androgens metformin hyperandrogenism testosterone birth control pills

Studysummary This article discusses PCOS in adolescents and highlights the importance of early diagnosis and treatment to prevent long-term health complications, noting increasing adolescent obesity may worsen symptoms.

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research Polycystic Ovary Syndrome in Adolescence

85 citations , June 2008 in “Annals of the New York Academy of Sciences”

This article proposes a hypothesis that hyperandrogenemia is the final common pathway for developing adolescent PCOS and emphasizes the importance of reducing androgen levels to mitigate risks of metabolic syndrome, diabetes, and infertility in adulthood.

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research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

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research Randomized, Double-Blind Clinical Evaluation of the Efficacy and Safety of Topical Eflornithine HCl 13.9% Cream in the Treatment of Women with Facial Hair

133 citations , July 2006 in “International Journal of Dermatology”

This study found that topical eflornithine HCl 13.9% cream effectively reduced facial hair in women, with a favorable safety profile.

research Development of Polycystic Ovary Syndrome: Involvement of Genetic and Environmental Factors

232 citations , December 2005 in “Andrology”

This review explores the hypothesis that polycystic ovary syndrome may originate in fetal life due to genetic predispositions and environmental influences, but it reports no new clinical findings.

research Hirsutism

271 citations , December 2005 in “New England journal of medicine/The New England journal of medicine”

This article discusses evaluation and treatment options for a 19-year-old woman with slowly progressive hair growth and reports no new clinical findings.

research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients

947 citations , February 2004 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, polycystic ovary syndrome was the most prevalent cause of androgen excess, and suppressive hormonal therapy improved hirsutism, menstrual dysfunction, and acne in most patients, though side effects were common.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations , January 2004 in “Fertility and Sterility”

This review discusses polycystic ovary syndrome, emphasizing its broad range of manifestations and associations with risks like type 2 diabetes and cardiovascular events, but reports no new clinical results.

research Developmental Origin of Polycystic Ovary Syndrome: A Hypothesis

430 citations , July 2002 in “Journal of Endocrinology”

This hypothesis paper suggests that PCOS may result from genetically determined ovarian hypersecretion of androgens, influencing hormone regulation and insulin resistance, with obesity further affecting its severity; no new clinical results are reported.

research Adult Polycystic Ovary Syndrome Begins in Childhood

124 citations , June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism”

This article reviews polycystic ovary syndrome in adolescents, highlighting its endocrine and metabolic features, and reports no new clinical findings; the etiology may involve early-life abnormalities in androgen production.

research American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Diagnosis and Treatment of Hyperandrogenic Disorders

89 citations , March 2001 in “Endocrine practice”

This article provides diagnosis and treatment guidelines for hyperandrogenic disorders in women but reports no new clinical results; it offers a summary of accepted scientific information and suggestions for clinical practice.

research Polycystic Ovary Syndrome: Clinical and Biochemical Features

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

This article discusses the heterogeneity of polycystic ovary syndrome, its association with insulin resistance, and its implications for long-term health, but reports no new clinical results.