Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to Its Formation and Is Progenitor Dependent

    September 2018 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Ka‐Wai Mok, Nivedita Saxena, Nicholas Heitman … Michael Rendl

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that dermal condensates are specified before hair follicle niche formation and require FGF20 and Wnt signaling for precursor specification, advancing understanding of niche formation and function during development.
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    Research cited in this study 21

    1. Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity Development · 2018
    2. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    3. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    4. Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis PLoS Biology · 2017
    5. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    6. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    7. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    8. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    9. Early Inductive Events in Ectodermal Appendage Morphogenesis Seminars in cell & developmental biology · 2014
    10. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    11. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    12. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    13. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    14. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    15. Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins Stem cells · 2010
    16. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    17. A Position Effect on TRPS1 Is Associated with Ambras Syndrome in Humans and the Koala Phenotype in Mice Human molecular genetics online/Human molecular genetics · 2008
    18. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    19. Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme: Implications for Hair Growth Control Journal of Investigative Dermatology · 2003
    20. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    21. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

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