Molecular Conversations and the Development of the Hair Follicle and Basal Cell Carcinoma

September 2010 in “ Cancer Prevention Research ”

Pamela Jo Harris, Naoko Takebe, S. Percy Ivy

basal cell carcinoma hair follicle Sonic hedgehog signaling insulin-like growth factor IGF axis IGF binding protein-2 stem cell niche cell differentiation BCC Shh signaling IGFBP-2

TLDR Overactive signaling in hair follicles can lead to skin cancer.

The document discussed the development of basal cell carcinoma (BCC) through the study of hair follicles, focusing on the role of Sonic hedgehog (Shh) signaling and its interaction with the insulin-like growth factor (IGF) axis. It highlighted the overexpression of IGF binding protein-2 (IGFBP-2) in hair follicle cells of mice with activated Shh signaling, which led to an expansion of the stem cell niche and inhibition of cell differentiation. This transformation was linked to the development of BCC, with evidence showing IGFBP-2 expression in human BCC as well.

View this study on aacrjournals.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

335 citations , March 2004 in “Development”

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations , October 2001 in “The FASEB Journal”

Noggin is necessary to start the hair growth phase in skin after birth.

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

research Hair Anatomy for the Clinician

139 citations , July 1991 in “Journal of The American Academy of Dermatology”

Understanding hair follicle anatomy helps diagnose hair disorders.

Related Community Posts Join

6 / 28 results

community When you're balding is it an absolute traumatic period of your life or do some people not care as much?

in Chat 92 upvotes 1 year ago

Balding can be traumatic for many, affecting self-esteem and social interactions, while others accept it more easily. Treatments mentioned include finasteride, minoxidil, and RU58841.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 2 years ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community The case of a 78 year old man who accidentally regrew his hair (published in the British Medical Journal)

in Chat 216 upvotes 1 week ago

A 78-year-old man regrew hair after suffering burns, suggesting that injury-induced healing processes might trigger hair growth. Microneedling and other treatments like minoxidil and finasteride are discussed as potential methods to stimulate similar regrowth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Doctor says i shouldn't take fin because its "hormonal"

in Finasteride/Dutasteride 105 upvotes 1 year ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

Similar Research

5 / 1000+ results

Signaling Involved in Hair Follicle Morphogenesis and Development