miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

    January 2018 in “BioMed Research International
    Ningxia Zhu, Keng Huang, Yang Liu, Huan Zhang, Emily Lin, Yang Zeng, Haihong Li, Yan‐Ming Xu, Bin Cai, Yanping Yuan, Yu Liu, Cheng Huang Lin
    Image of study
    TLDR miR-195-5p reduces hair growth ability in cells by blocking a specific growth signal.
    In the 2018 study, researchers explored the impact of miR-195-5p on the hair follicle inductivity of dermal papilla (DP) cells, particularly its role in the Wnt/β-catenin signaling pathway. They discovered that miR-195-5p was more abundant in late-passage DP cells, which lack the ability to induce hair follicle development, and less abundant in early-passage DP cells, which retain this inductive capacity. Overexpression of miR-195-5p resulted in a dose-dependent reduction of β-catenin expression and decreased levels of LRP6 and other genes involved in hair follicle inductivity. The study concluded that miR-195-5p suppresses Wnt/β-catenin signaling, which may lead to the loss of hair follicle inductivity in DP cells. The findings provide potential targets for maintaining or restoring the hair-inducing capacity of DP cells and were supported by data available in the Gene Expression Omnibus under accession number GSE77825.
    View this study on hindawi.com →

    Cited in this study