Minoxidil-Induced Hypertrichosis: Pathophysiology, Clinical Implications, and Therapeutic Strategies

    August 2024 in “ JAAD reviews. ”
    Deesha Desai, Ambika Nohria, Anna Brinks … Kristen I. Lo Sicco
    Studysummary This review reports that low-dose oral minoxidil can cause hypertrichosis due to increased systemic absorption, and highlights the importance of patient-centered care to manage the psychosocial impacts of this side effect effectively.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022
    2. Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients Journal of The American Academy of Dermatology · 2021
    3. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    4. Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients Journal of The American Academy of Dermatology · 2021
    5. Characterization and Management of Hypertrichosis Induced by Low-Dose Oral Minoxidil in the Treatment of Hair Loss Journal of The American Academy of Dermatology · 2020
    6. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    7. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    8. Female Pattern Hair Loss: A Pilot Study Investigating Combination Therapy with Low-Dose Oral Minoxidil and Spironolactone International Journal of Dermatology · 2017
    9. Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management Current pharmaceutical design · 2016
    10. Congenital Generalized Hypertrichosis: The Skin as a Clue to Complex Malformation Syndromes ˜The œItalian Journal of Pediatrics/Italian journal of pediatrics · 2015
    11. From Flint Razors to Lasers: A Timeline of Hair Removal Methods Journal of Cosmetic Dermatology · 2013
    12. Androgens and Hair Growth Dermatologic Therapy · 2008
    13. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    14. Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls Journal of The European Academy of Dermatology and Venereology · 2003
    15. Hypertrichosis Journal of the American Academy of Dermatology · 2003
    16. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    17. Causes and Management of Hypertrichosis American Journal of Clinical Dermatology · 2002
    18. Hair Removal Clinics in Dermatology · 2001
    19. Topical Eflornithine: Efficacy in Reducing Unwanted Facial Hair Growth in Women American journal of clinical dermatology · 2001
    20. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    21. Spironolactone Therapy in Hypertrichosis European journal of endocrinology · 1996
    22. The Effect of an Oral Contraceptive Containing Ethinylestradiol and Desogestrel on Hair Growth and Hormonal Parameters of Hirsute Women International Journal of Gynecology & Obstetrics · 1986
    23. Pharmacology and Pharmacokinetics of Minoxidil Journal of Cardiovascular Pharmacology · 1980

    Related research 7

    1. Minoxidil-Induced Hypertrichosis in a Child with Alopecia Areata Indian Dermatology Online Journal · 2017
    2. Infantile Generalized Hypertrichosis Caused by Topical Minoxidil Anais Brasileiros de Dermatologia · 2016
    3. Minoxidil Induced Hypertrichosis in a 2-Year-Old Child F1000Research · 2013
    4. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    5. Diffuse Hypertrichosis During Treatment with 5% Topical Minoxidil British Journal of Dermatology · 1997
    6. Hypertrichosis Due to Minoxidil British Journal of Dermatology · 1979
    7. Minoxidil-Induced Hypertrichosis: Treatment with Calcium Thioglycolate Depilatory PubMed · 1977