Bicalutamide: A Review

    September 2024 in “ Journal of Cutaneous and Aesthetic Surgery ”
    Shayna Aulakh, Venkataram Mysore
    Studysummary This review focuses on the pharmacological properties, indications, contraindications, and safety profile of bicalutamide, a non-steroidal androgen receptor antagonist, in dermatological research, particularly its off-label use for improving female pattern hair loss as measured by Sinclair grading.
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    Research cited in this study 16

    1. Mesotherapy With Bicalutamide: A New Treatment for Androgenetic Alopecia International Journal of Trichology · 2023
    2. Bicalutamide and the New Perspectives for Female Pattern Hair Loss Treatment: What Dermatologists Should Know Journal of Cosmetic Dermatology · 2022
    3. Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis Pharmaceutics · 2021
    4. Bicalutamide Improves Minoxidil-Induced Hypertrichosis in Female Pattern Hair Loss: A Retrospective Review of 35 Patients Journal of The American Academy of Dermatology · 2021
    5. Clinicopathological Characteristics and Treatment Outcomes of Fibrosing Alopecia in a Pattern Distribution: A Retrospective Cohort Study Journal of the European Academy of Dermatology and Venereology · 2021
    6. Bicalutamide: A Potential New Oral Antiandrogenic Drug for Female Pattern Hair Loss Journal of The American Academy of Dermatology · 2020
    7. Safety of Oral Bicalutamide in Female Pattern Hair Loss: A Retrospective Review of 316 Patients Journal of The American Academy of Dermatology · 2020
    8. Impact of Estrogens in Males and Androgens in Females ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2019
    9. Female Pattern Hair Loss and Androgen Excess: A Report From the Multidisciplinary Androgen Excess and PCOS Committee The Journal of Clinical Endocrinology and Metabolism · 2019
    10. Androgens in Women: Role in Androgen-Mediated Cutaneous Disorders Journal of The American Academy of Dermatology · 2018
    11. Gender-Affirming Hormone Therapy for Transgender Females Clinical Obstetrics and Gynecology · 2018
    12. Minoxidil Promotes Hair Growth Through Stimulation of Growth Factor Release from Adipose-Derived Stem Cells International Journal of Molecular Sciences · 2018
    13. Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism: A Double-Blind Randomized Controlled Trial The Journal of Clinical Endocrinology & Metabolism · 2017
    14. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    15. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    16. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013