Utilizing Lipid Bond Technology With Molecular Lipid Complex to Provide Lipid Treatment for Damaged Hair

January 2025 in “ Dermatology Research and Practice ”

Nam Hai Lai, Thi Hong Ngoc Dang, Thuy Thu Nguyen, Dinh‐Van Phan

lipid bond technology molecular lipid complex nano-microemulsions plant oil triglycerides hair lipids bleaching lipid molecules cuticle integrity SEM analysis 369LAB Moonshot Biotech

Studysummary This study found that using 369LAB Lipid Bond, derived from plant oil triglycerides, can restore lipid content in damaged hair to natural levels and improve hair strength, integrity, and resilience after a single application, with benefits persisting even after discontinuation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study evaluates the 369LAB Lipid Bond technology, developed by MOONSHOT BIOTECH PTE. LTD., for treating damaged hair. This technology uses nano-microemulsions of plant oil triglycerides to mimic natural hair lipids, enhancing absorption and bioavailability. After artificially damaging hair through bleaching, the treatment restored lipid levels from 5.506% in bleached hair to 8.811%, comparable to natural hair. The small lipid molecules (20 to 300 nm) penetrate deeply, repairing damage, improving hair strength, and restoring cuticle integrity. SEM analysis confirmed reduced structural damage, and the product is non-sticky and sustainable, offering long-term benefits for haircare formulations. The study was funded by Moonshot Biotech PTE. LTD. with no conflicts of interest.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

24 / 24 results

research Impact of Hair Damage on the Penetration Profile of Coconut, Avocado, and Argan Oils into Caucasian Hair Fibers

April 2024 in “Cosmetics”

Different oils affect hair flexibility and strength, with their impact varying on whether hair is virgin or bleached.

research Hair Lipid Structure: Effect of Surfactants

2 citations , July 2023 in “Cosmetics”

In this study, researchers highlighted that while hair lipids are crucial for hair health and protection, surfactants in shampoos and conditioners can partially remove these lipids, potentially affecting hair structure, though the exact mechanisms remain poorly understood and require further investigation.

research Hair Growth Promotion of Argan Oil Nanoemulsion Hair Tonic Preparation in Mice

September 2022 in “KnE medicine”

This study found that hair tonic nanoemulsions containing 1%, 2%, and 3% argan oil promoted hair growth in mice over 21 days.

research Advances in the Chemical Structure of the Hair Surface, Surface Forces and Interactions

1 citations , March 2021

This chapter provides an overview of the complex chemical and physical structure of the hair surface, detailing how factors like ethnicity, environmental stress, and cosmetic treatments can alter its properties and influence the adhesion of hair care products.

research Penetration of Different Molecular Weight Hydrolysed Keratins into Hair Fibres and Their Effects on the Physical Properties of Textured Hair

7 citations , September 2020 in “International Journal of Cosmetic Science”

This study investigated the effects of wool-derived hydrolysed keratin peptides on relaxed textured hair and found that mid- and high-molecular weight peptides improved mechanical strength and reduced breakage in different humidity conditions.

research Known and Unknown Features of Hair Cuticle Structure: A Brief Review

27 citations , May 2019 in “Cosmetics”

This review explores the structure and development of the hair cuticle, highlighting difficulties in studying some aspects and proposing new experimental approaches, but reports no new clinical results.

research Degradation of Hair Surface: Importance of 18-MEA and Epicuticle

25 citations , May 2019 in “Cosmetics”

This paper reviews the surface degradation of hair and describes how combining 18-MEA with specific surfactants can maintain hydrophobicity on bleached and weathered hair surfaces.

research Development and Efficacy Evaluation of Hair Care Formulations Containing Vegetable Oils and Silicone

42 citations , December 2018 in “International Journal of Phytocosmetics and Natural Ingredients”

This study found that hair care formulations containing vegetable oils like Brazil nut and olive oil improved hair strength, shine, and combability more effectively than those with silicone.

research The Physical and Chemical Disruption of Human Hair After Bleaching – Studies by Transmission Electron Microscopy and Redox Proteomics

30 citations , September 2018 in “International Journal of Cosmetic Science”

In this study, researchers observed that cosmetic peroxide bleaching causes oxidative damage and protein loss in human hair, not only affecting the cuticle but also deeper cortical structures, correlating with bleaching severity.

research Analysis of Lipids in the Medulla of Japanese Hair and Their Function

7 citations , April 2018 in “Cosmetics”

This study found that the medulla of Japanese hair contains unsaturated lipids such as squalene and oleic acid, which may contribute to hair glossiness.

research Size-Dependent Penetration of Nanoemulsions into Epidermis and Hair Follicles: Implications for Transdermal Delivery and Immunization

96 citations , April 2017 in “Oncotarget”

This study found that nanoemulsions of different sizes vary in their ability to penetrate skin layers, with smaller sizes aiding transdermal delivery and potential applications in transcutaneous immunization.

research Structural Analysis of the Outermost Hair Surface Using TOF-SIMS with Gas Cluster Ion Beam Sputtering

11 citations , January 2016 in “Biointerphases”

This study suggests that the outermost hair cuticle surface is rich in 18-methyleicosanic acid (18-MEA), supporting previous findings of its multilayer lipid and protein structure.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations , August 2014 in “Lipids”

This study found that unsaturated fatty acids are more abundant in the cortex of human hair than on its surface, and steryl glycoside-like lipids may help bind the cuticle to the cortex.

research The Ethnic Differences in Hair Damage and Integral Hair Lipid After Ultraviolet Radiation

59 citations , January 2013 in “Annals of Dermatology”

In this study, researchers found that Asian hair contains more integral lipids than European or African hair, which may protect it better from UV-induced damage.

research The Physical Properties of Hair Fibers

7 citations , December 2011 in “Springer eBooks”

I'm sorry, but I can't provide a summary without the content of the document.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.

research Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin

46 citations , January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Insig deficiency in the skin of mice causes cholesterol precursors to accumulate, leading to defective hair development and skin abnormalities, which were alleviated by simvastatin treatment.

research Investigation of Penetration Abilities of Various Oils into Human Hair Fibers

11 citations , January 2006 in “International Journal of Cosmetic Science”

Some oils can penetrate hair and reduce the stickiness between fibers, but mineral oil cannot.

research Penetration of Cationic Conditioning Compounds into Hair Fibers: A TOF-SIMS Approach

2 citations , January 2006 in “International Journal of Cosmetic Science”

This study investigated the penetration of a low-molecular-weight cationic conditioning compound into the hair cortex and suggests it may improve hair's fatigue resistance.

research Integral Lipid in Human Hair Follicle

30 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study discovered that the lipid in human hair follicles is mainly located in the hair cuticle and keratinized inner root sheath, distinct from sebaceous and epidermal lipids, suggesting a potential role as a "hair barrier.

research Mapping Penetration of Cosmetic Compounds into Hair Fibers Using Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS)

3 citations , September 2005 in “International Journal of Cosmetic Science”

This study found that monounsaturated oils like olive oil penetrate hair fibers effectively, whereas polyunsaturated oils typically do not penetrate beyond the cuticle.

research Change in Surface Chemistry of the Cuticle of Human Hair by Chemical and Photochemical Oxidation

10 citations , March 2005 in “International Journal of Cosmetic Science”

This study found that photochemical and cosmetic chemical oxidation of hair causes surface damage by delipidation and acid formation, which can be characterized and quantified using microfluorometry and X-ray photoelectron spectroscopy.

Secondary Ion Mass Spectrometric Investigation of Penetration of Coconut and Mineral Oils into Human Hair Fibers: Relevance to Hair Damage

research Secondary Ion Mass Spectrometric Investigation of Penetration of Coconut and Mineral Oils into Human Hair Fibers: Relevance to Hair Damage

11 citations , June 2001 in “PubMed”

Coconut oil can penetrate hair better than mineral oil, potentially protecting against damage.

research Hair: Its Structure and Response to Cosmetic Preparations

86 citations , January 1996 in “Clinics in dermatology”

This review discusses the effects of protein-based cosmetics on hair properties and reports no new research findings, suggesting potential benefits for developing advanced, sustainable hair products.