Prolonged Use of Finasteride-Induced Gonadal Sex Steroids Alterations, DNA Damage, and Menstrual Bleeding in Women

    January 2020 in “ Bioscience Reports ”
    Gadah Albasher, May Bin-Jumah, Saleh A. Al-Farraj … Wedad Saeed Al-Qahtani
    Studysummary This study found that prolonged use of finasteride in women led to altered levels of sex steroids, DNA damage, and increased menstrual bleeding, suggesting adverse health effects without clear benefits for androgenetic alopecia treatment.
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    Research cited in this study 8

    1. Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice Human & Experimental Toxicology · 2019
    2. Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products Endocrinology · 2017
    3. Risk of Erectile Dysfunction Associated with Use of 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population-Based Studies Using the Clinical Practice Research Datalink BMJ · 2016
    4. Finasteride 5 mg/Day Treatment of Patterned Hair Loss in Normo-Androgenetic Postmenopausal Women International Journal of Trichology · 2013
    5. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    6. Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations British Journal of Dermatology · 2006
    7. Androgenetic Alopecia in Women Journal of Investigative Dermatology Symposium Proceedings · 2003
    8. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998