ISX9, a Small Molecule Targeting Axin, Activates Wnt/β-Catenin Signaling and Promotes Hair Regrowth

    August 2022
    Sapna Sayed, Jiaxing Song, Ling Wang … Desheng Lu
    Studysummary This study identified ISX9 as a novel agonist of the Wnt/β‐catenin pathway, which promoted hair regrowth in mice and may offer a therapeutic approach for alopecia.
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    Research cited in this study 20

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities Signal Transduction and Targeted Therapy · 2022
    3. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    4. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    5. Macrophage-Derived Extracellular Vesicle Promotes Hair Growth Cells · 2020
    6. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    7. Baicalin Increases Hair Follicle Development by Enhancing Canonical Wnt/β-Catenin Signaling and Activating Dermal Papilla Cells in Mice International Journal of Molecular Medicine · 2018
    8. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling Molecular therapy · 2017
    9. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    10. The Annual Changes of Clinical Manifestation of Androgenetic Alopecia Clinic in Korean Males and Females: An Outpatient-Based Study Annals of Dermatology · 2013
    11. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    12. Drugs and Hair Loss: Mechanisms and Clinical Implications Dermatologic Clinics · 2012
    13. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    14. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    15. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    16. Minoxidil: An Underused Vasodilator for Resistant or Severe Hypertension Journal of Clinical Hypertension · 2004
    17. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    18. Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia British Journal of Dermatology · 2000
    19. Management of Androgenetic Alopecia American Journal of Clinical Dermatology · 2000
    20. Minoxidil Annals of Internal Medicine · 1981