Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

    July 2016 in “Development
    Emanuel Rognoni, Céline Gomez, Angela Oliveira Pisco, Emma L. Rawlins, Benjamin D. Simons, Fiona M. Watt, Ryan R. Driskell
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    TLDR Blocking β-catenin in skin cells improves hair growth during wound healing.
    The study found that inhibiting β-catenin signaling in dermal fibroblasts can enhance hair follicle regeneration during wound healing. The researchers used mice and found that β-catenin ablation in fibroblasts promoted hair follicle regeneration in neonatal and adult mouse wounds while β-catenin activation reduced hair follicle regeneration in neonatal wounds. The study suggests that inhibiting β-catenin signaling in dermal fibroblasts could be a potential therapeutic strategy for promoting hair growth and wound healing.
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