Elevated Serum Heat Shock Protein-70 and Interleukin-15: Prognostic Biomarkers Correlating with Clinical Severity and Diagnostic Efficacy in Active Alopecia Areata

    January 2026 in “ Journal of the Egyptian Womenʼs Dermatologic Society ”
    Fatima H. Sabih, Maha F. Smaism, Wisam A. Ameen
    Studysummary This study observed that male patients with alopecia areata had elevated serum levels of HSP70 and IL-15, with levels increasing alongside disease severity, suggesting these markers are strongly associated with the disease's pathogenesis.
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    Research cited in this study 14

    1. Alopecia Areata Is Associated With An Increased Risk For Prediabetes And Obesity: A Nationwide Case-Control Study Journal of Personalized Medicine · 2025
    2. The Demographic and Clinical Profile of Patients With Alopecia Areata in Syria: A Study Letter Cosmoderma · 2024
    3. Association of Low Serum Ferritin Levels in Patients With Alopecia Areata: A Case-Control Study Proceedings · 2024
    4. IL-15 in T-Cell Responses and Immunopathogenesis Immune Network · 2024
    5. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023
    6. Interleukin-15 and Tumor Necrosis Factor-Alpha in Iraqi Patients with Alopecia Areata Dermatology Research and Practice · 2023
    7. An Overview of JAK/STAT Pathways and JAK Inhibition in Alopecia Areata Frontiers in immunology · 2022
    8. Interleukin 15 Gene Polymorphism in Patients with Alopecia Areata The Egyptian Journal of Hospital Medicine · 2022
    9. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    10. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    11. Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options Clinical and Experimental Medicine · 2021
    12. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    13. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    14. Evaluation of Serum Zinc Level in Patients With Newly Diagnosed and Resistant Alopecia Areata International Journal of Dermatology · 2015