Interleukin 15 Gene Polymorphism in Patients with Alopecia Areata

July 2022 in “ The Egyptian Journal of Hospital Medicine ”

Aml Mohamed Montaser, Mohmed Helmy ELnabalawy, Soheir Abdelgaber Eltoukhy, Ahmed Fawzi Ismael

Interleukin 15 IL-15 Alopecia Areata IL-15 receptor blocker

TLDR Targeting IL-15 may help treat Alopecia Areata.

The study investigated the association of IL-15 genetic polymorphism (rs17015014) with the risk and severity of Alopecia Areata (AA) in 50 patients and 50 control subjects. The distribution of IL-15 gene polymorphism among cases and controls showed no significant differences in genotypes or alleles. Additionally, no significant associations were found between IL-15 single nucleotide polymorphism and the severity of AA as measured by SALT scores, nor with the disease course, recurrence, site of affection, or dermoscopic findings. The study concluded that IL-15 genetic polymorphism was not associated with the development or severity of AA.

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