Hair Follicle Development and Related Gene and Protein Expression in Rex Rabbits During the First 8 Weeks of Life

September 2018 in “ Asian-Australasian Journal of Animal Sciences ”

Zhenyu Wu, Liang-Zhan Sun, Gongyan Liu, Hongli Liu, Hanzhong Liu, Zhiju Yu, Shuang Xu, Fuchang Li, Yinghe Qin

hair follicle development IGF-I EGF BMP2 TGFβ-1 TGFβ-2 TGFβ-3 β-Catenin Wnt10b

TLDR Rex rabbits' hair follicles develop dynamically in the first 8 weeks, with key genes and proteins changing over time.

The study on Rex rabbits during their first 8 weeks of life revealed significant changes in hair follicle development and gene expression. Key genes such as IGF-I, EGF, BMP2, TGFβ-1, TGFβ-2, TGFβ-3, and β-Catenin played crucial roles, with their expression levels varying with age. Notably, IGF-I, EGF, TGFβ-2, and TGFβ-3 levels increased over time, while BMP2 and TGFβ-1 decreased after 2 weeks. Wnt10b and β-Catenin protein levels were lowest at 2 and 4 weeks. The study, involving 6 rabbits per group, highlighted the dynamic nature of hair follicle development and the involvement of specific genes and proteins, suggesting potential regulation at the translational level.

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Hair Follicle Development and Related Gene and Protein Expression in Rex Rabbits During the First 8 Weeks of Life

Research cited in this study

research Tuning Wnt Signals for More or Fewer Hairs

research Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

research The Hair Cycle

research Molecular Biology of Hair Morphogenesis: Development and Cycling

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research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

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