Gut Microbiota-Derived Metabolites in Keloid and Hypertrophic Scarring
September 2025
in “
Frontiers in Microbiology
”
keloids hypertrophic scars collagen deposition chronic inflammation gut microbiota-derived metabolites short-chain fatty acids bile acids tryptophan derivatives immune responses pro-fibrotic signaling pathways TGF-β Wnt/β-catenin dermal fibroblast skin-gut-fibrosis axis gut microbiota collagen inflammation fibroblast skin-gut connection
Studysummary This review article proposes a possible skin-gut-fibrosis axis, suggesting that gut microbial metabolites may influence the development of keloids and hypertrophic scars by affecting immune responses and fibrotic signaling pathways, although direct evidence in skin fibrosis remains limited.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
Read the full study on frontiersin.org →