Graham-Little-Piccardi-Lassueur Syndrome: Two Case Reports and Review of the Literature

November 2020 in “ Acta Medica Bulgarica/Acta medica Bulgarica ”

L. Dourmishev, N. Mironova, I. V. Popov, Dina S. Rusinova, Maria Balabanova, Ljubka Miteva

Graham-Little-Piccardi-Lassueur syndrome cicatricial alopecia non-cicatricial alopecia follicular lichen planus pruritic skin lesions corticosteroids GLPLS scarring alopecia itchy skin lesions steroids

Studysummary This case report details two patients with Graham-Little-Piccardi-Lassueur syndrome who showed marked skin lesion improvement with corticosteroid treatment, though cicatricial scalp alopecia remained unresponsive.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare condition marked by cicatricial alopecia of the scalp, non-cicatricial alopecia of the axilla and groin, and follicular lichen planus eruptions. Two cases were reported: a 71-year-old woman and a 48-year-old man, both presenting with pruritic skin lesions and hair loss. Laboratory tests were normal, and histological examinations confirmed GLPLS. Treatment with systemic and local corticosteroids led to significant improvement in skin lesions, but cicatricial scalp alopecia did not respond to the treatment.

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research What's New in Cicatricial Alopecia?

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research Graham Little-Piccardi-Lassueur Syndrome Associated with Androgen Insensitivity Syndrome (Testicular Feminization)

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research Cicatricial (Scarring) Alopecia: Clinical Presentations, Etiologies, and Histopathologic Features

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