Genetic and Histological Correlation Between the Musk Gland and Skin of Chinese Forest Musk Deer

October 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Long Li, Heran Cao, Jinmeng Yang, Yuxuan Ma, Tianqi Jin, Yang Wang, Zhenpeng Li, Yining Chen, Huihui Gao, Chao Zhu, Tianhao Yang, Yalong Deng, Fangxia Yang, Wuzi Dong

Sox9 Caveolin1 Androgen receptor sebum secretion

TLDR Musk glands and skin in Chinese forest musk deer are closely related and share many genes.

The study investigated the correlation between skin tissues and musk glands in Chinese forest musk deer, focusing on the expression of Sox9, Caveolin1, and Androgen receptor (AR), which are involved in sebum secretion. Using various methods such as transcriptomic data analysis, western blotting, and immunohistochemistry, the study found that 88.24% of genes were co-expressed in both skin and musk gland tissues. The results indicated that Sox9, Caveolin1, and AR were expressed in these tissues, suggesting a strong correlation between them and highlighting their potential roles in regulating sebum secretion. The study also noted anatomical differences between adult and 4-month-old deer, with only adult males having fully developed glandular structures.

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