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Glossary Caveolin-1

protein involved in cell membrane structure and signaling

Caveolin-1 (CAV1) is a protein that plays a crucial role in the formation of caveolae, which are small invaginations on the cell membrane involved in various cellular processes such as signal transduction and endocytosis. It is also important in regulating lipid metabolism and maintaining cellular structure. In the context of hair biology, alterations in Caveolin-1 expression have been linked to conditions like alopecia, where hair loss occurs.

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A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

research A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

4 citations , May 2021 in “Biomedicines”

This review explores the potential role of caveolin-1 in cicatricial alopecia, particularly frontal fibrosing alopecia, and discusses possibilities for targeted therapies without providing new research results.

Spatial Transcriptomic Analysis of Imiquimod-Treated Mouse Skin Reveals Deregulation of Lipid Raft-Associated Markers Reversible by Caveolin Scaffolding Domain Peptide

research 1619 Spatial transcriptomic analysis of imiquimod-treated mouse skin reveals deregulation of lipid raft-associated markers which could be reversed by re-introduction of caveolin scaffolding domain peptide

April 2023 in “Journal of Investigative Dermatology”

This study suggests that caveolin-1 may be a potential target for treating psoriasis, as its downregulation was linked to psoriasis markers that improved with soluble caveolin scaffolding domain peptide treatment.

Deregulation of Toll Like Receptor Signaling and Association With Caveolin-1 in Lichen Planopilaris Reveals a Novel Mechanism in Pathogenesis of Scarring Alopecia

research 1425 Deregulation of toll like receptor signaling and association with caveolin-1 in lichen planopilaris reveals a novel mechanism in pathogenesis of scarring alopecia

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that the expression and localization of toll-like receptors and caveolin-1 in lichen planopilaris may influence cicatricial alopecia pathobiology and that downregulating caveolae could offer a novel management strategy.

research 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs

July 2024 in “Journal of Investigative Dermatology”

Bioengineered skin models aging well, useful for studying aging and testing treatments.

research Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that Sox9, Caveolin1, and Androgen receptor genes are expressed in both skin tissues and musk glands of Chinese forest musk deer, suggesting their importance in these tissues.

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