Generating hair follicle inductive dermal papillae cells from adipose derived mesenchymal stem cells

January 2018 in “ Belarusian State Pedagogical University repository (Belarusian State Pedagogical University) ”

Alice Clare Brown

dermal papillae adipose-derived mesenchymal stem cells folliculogenesis Wnt signaling β-catenin Versican hanging drop method DP cells ASCs Wnt/β-catenin signaling

TLDR Adipose-derived stem cells can be used to create cells that help grow new hair.

This study aimed to achieve de novo folliculogenesis by generating dermal papillae (DP) like-spheroids from adipose-derived mesenchymal stem cells (ASCs) to induce hair follicle formation. The researchers used the hanging drop method and Wnt exposure to direct ASCs towards a DP-like fate, mimicking embryological hair follicle induction. Gene expression analysis revealed a significant increase in Versican expression, suggesting that Wnt/β-catenin signaling regulates DP cell growth. The resulting spheroids exhibited similar morphology and gene expression to human hair follicle DP cells. This method, using easily obtainable cells, showed potential for rapid translation to clinical trials for hair regeneration.

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