Refractory Alopecia Areata of the Beard: Novel Improvement Through Exosome Therapy With Signs of Hair Repigmentation

    December 2025 in “ Clinical Case Reports ”
    Asem Shadid, Khalid Nabil Nagshabandi, Abdullah Al‐Omair
    Studysummary This study found that exosome injections from human umbilical cord, with or without polydeoxyribonucleotide, promoted regrowth and repigmentation of white beard hairs and improved scarring in a 35-year-old man with refractory alopecia areata, suggesting potential as a minimally invasive regenerative treatment.
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    Research cited in this study 9

    1. Hair Repigmentation of Poliosis Circumscripta in Androgenetic Alopecia Patient Treated With Exosomes and Fractional Picosecond Laser Journal of Cosmetic Dermatology · 2024
    2. Adipose-Derived Stem Cell Exosomes Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicle Growth by Activating Wnt/Beta-Catenin Pathway Stem Cells International · 2023
    3. Development and Characterization of Polydeoxyribonucleotide Loaded Chitosan Polyplex for Wound Healing International journal of biological macromolecules · 2023
    4. Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia Pharmaceutics · 2022
    5. The Novel Mechanisms and Applications of Exosomes in Dermatology and Cutaneous Medical Aesthetics Pharmacological research · 2021
    6. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    7. Current Advances in Stem Cell-Based Therapies for Hair Regeneration European Journal of Pharmacology · 2020
    8. Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss Wound Repair and Regeneration · 2014
    9. Alopecia Areata: A New Treatment Plan Clinical, cosmetic and investigational dermatology · 2011