Foxc1 reinforces quiescence in self-renewing hair follicle stem cells

February 2016 in “ Science ”

Li Wang, Julie A. Siegenthaler, Robin D. Dowell, Rui Yi

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Research cited in this study

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research Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation

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Hormones during pregnancy and lactation keep skin stem cells inactive, preventing hair growth.

research In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators

173 citations , January 2014 in “Nature Cell Biology”

Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.

research Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling

158 citations , February 2012 in “Journal of Investigative Dermatology”

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage

191 citations , September 2011 in “Cell stem cell”

Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

73 citations , June 2001 in “Endocrinology”

Prolactin affects when mice shed and grow hair.

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