Qualitative Study for Finasteride Detection in the Prostate Delivered by Reversible Inhibition of Sperm Under Guidance – Prostate Hair (RISUG-PH) Vas Injectable Implant

    Santosh Gupta, Jovana Bisevac, Sujoy K. Guha
    Studysummary This study confirmed that an injectable implant known as RISUG-PH™, when administered via the vas deferens, successfully delivers the drug Finasteride to the prostate in male rats for up to 28 days, suggesting a potential localized alternative to oral delivery methods.
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    Research cited in this study 6

    1. The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression Korean Journal of Urology · 2014
    2. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    3. Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry Drug Metabolism and Disposition · 2009
    4. Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat Biochemical Pharmacology · 2001
    5. Structural Characterization of Polymorphs and Molecular Complexes of Finasteride Journal of Molecular Structure · 1999
    6. Picogram Determination of Finasteride in Human Plasma and Semen by High-Performance Liquid Chromatography with Atmospheric-Pressure Chemical-Ionization Tandem Mass Spectrometry Journal of Chromatography B: Biomedical Sciences and Applications · 1994

    Related research 6

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. Clinical Observation on Acne Patients Taking Finasteride China Medical Abstract of Dermatology · 2013
    3. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    4. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    5. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    6. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995