Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells
March 2019
in “
Journal of immunology research
”
Valproic Acid VPA epigenetic changes gene expression cell cycle differentiation apoptosis anti-inflammatory response myeloid hematopoietic progenitors macrophage activity intracellular bacterial infections tuberculosis dendritic cell maturation neutrophil function natural killer cell function NK cell function eosinophils basophils mast cells cytokine production T lymphocyte function B lymphocyte function regulatory T cells Treg autoimmune diseases cancer infectious diseases T cell function B cell function
Studysummary This review discusses the effects of valproic acid on immune cell activation and gene expression, potentially influencing infection outcomes and suggesting its promise for autoimmune and hypersensitivity condition management.
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