Ex Vivo Permeation Parameters and Skin Deposition of Melatonin-Loaded Microemulsion for Treatment of Alopecia
May 2022
in “Future Journal of Pharmaceutical Sciences”
TLDR Melatonin-loaded microemulsion could be a promising treatment for hair loss.
The document discusses a study on the development and evaluation of a melatonin-loaded microemulsion (MEL ME) for treating androgenic alopecia. The MEL ME was formulated using coconut oil, Tween 80, and PEG 400, and was characterized for its size, uniformity, and stability. An ex vivo permeation study through rat skin showed that MEL ME had low steady-state skin flux and high stratum corneum deposition, indicating a controlled release manner. The study concluded that MEL ME could be a promising candidate for further permeation and in vivo studies for androgenic alopecia treatment.
View this study on fjps.springeropen.com →
Cited in this study
research Developing formulations for drug follicular targeting: Nanoemulsions loaded with minoxidil and clove oil
research Protective Effects of Melatonin on the Skin: Future Perspectives
Melatonin, usually known for sleep regulation, also has antioxidant properties that can protect skin, stimulate hair growth, and improve skin conditions, with topical application being more effective than oral use.
research The Medical and Psychosocial Associations of Alopecia: Recognizing Hair Loss as More Than a Cosmetic Concern
Alopecia is linked to various health and mental conditions, impacts life quality, and needs medical attention beyond its cosmetic effects.
research Melatonin vitamin C-based nanovesicles for treatment of androgenic alopecia: Design, characterization and clinical appraisal
research Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting
Eucalyptol and oleic acid in nanoemulsions improve minoxidil delivery to hair follicles, potentially enhancing hair loss treatment.
research A novel approach for follicular delivery of minoxidil for treatment of alopecia
Scientists developed a new method to deliver alopecia treatment directly to hair follicles, which could be a promising treatment for hair loss and other hair diseases.
research Investigation of drug partition property in artificial sebum
The conclusion is that measuring how drugs partition into artificial sebum is important for predicting their delivery into hair and sebaceous follicles, and it provides better information than traditional methods.
research On the Role of Melatonin in Skin Physiology and Pathology
Melatonin is important for skin health and protection, and can be made by the skin or applied to it.