Comparative Efficacy of Oral Dutasteride and Low, Medium, and High-Dose Oral Minoxidil: A Six-Month Prospective Trichoscopic and Clinical Study

    February 2026 in “ Frontiers in Medicine ”
    M. Larios-Cárdenas, D.G. Quiñones-Hernández, M. León Quintero-Loreto … L.E. Sánchez-Dueñas
    Studysummary This study found that oral minoxidil was associated with short-term improvements in clinical severity for androgenetic alopecia, whereas oral dutasteride did not show significant early clinical changes in the six-month follow-up.
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    Research cited in this study 19

    1. Enhanced Stratification of Male Pattern Hair Loss Using AI Through Novel Loss Region Ratio Analysis Scientific Reports · 2025
    2. Relative Efficacy of Minoxidil in Combination With Other Treatments for Androgenic Alopecia: A Network Meta-Analysis Based on Randomized Controlled Trials Frontiers in Medicine · 2025
    3. Oral Minoxidil 2.5mg vs 5mg for Male Androgenetic Alopecia: A Double-Blind Randomized Clinical Trial Journal of the American Academy of Dermatology · 2025
    4. P077 Updates on Trichoscopy in Diagnosing Scalp Disorders: A Systematic Review of Diagnostic Accuracy, Sensitivity and Specificity British Journal of Dermatology · 2025
    5. Evaluating the Accuracy of Patient-Reported Hair Outcomes Versus Trichometric Measurements in PRP Therapy Archives of Dermatological Research · 2025
    6. Immune and Non-Immune Interactions in the Pathogenesis of Androgenetic Alopecia Clinical Reviews in Allergy & Immunology · 2025
    7. Oral Minoxidil Versus Topical Minoxidil for Male Androgenetic Alopecia JAMA dermatology · 2024
    8. Trichoscopy of Androgenetic Alopecia: A Systematic Review Journal of clinical medicine · 2024
    9. The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia International Journal of Molecular Sciences · 2024
    10. Divergent Progression Pathways in Male Androgenetic Alopecia and Female Pattern Hair Loss: Trichoscopic Perspectives Journal of Cosmetic Dermatology · 2024
    11. MRNA Levels of Aromatase, 5α-Reductase Isozymes, and Prostate Cancer-Related Genes in Plucked Hair from Young Men with Androgenic Alopecia International Journal of Molecular Sciences · 2023
    12. Androgenetic Alopecia: Therapy Update Drugs · 2023
    13. Mapping the Hair Density, Thickness, and Volume in Normal and Androgenetic Alopecia Subjects With the Digital Microscope JEADV Clinical Practice · 2022
    14. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    15. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    16. Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia JAMA Dermatology · 2021
    17. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    18. Effectiveness and Safety of Oral Dutasteride for Male Androgenetic Alopecia in Real Clinical Practice: A Descriptive Monocentric Study Dermatologic Therapy · 2019
    19. Value of Trichoscopy Versus Trichogram for Diagnosis of Female Androgenetic Alopecia International Journal of Trichology · 2012