Oral Minoxidil 2.5mg vs 5mg for Male Androgenetic Alopecia: A Double-Blind Randomized Clinical Trial

September 2025 in “ Journal of the American Academy of Dermatology ”

Larissa Pierri Carvalho Fonseca, Hélio Amante Miot, Christine Rachelle Prescendo Chaves, Paulo Müller Ramos

oral minoxidil androgenetic alopecia male androgenetic alopecia AGA hair regrowth Rogaine

TLDR Both 2.5 mg and 5 mg doses of oral minoxidil are effective for hair regrowth in men with hair loss.

This double-blind randomized clinical trial compared the efficacy and safety of 2.5 mg and 5 mg doses of oral minoxidil for treating male androgenetic alopecia (AGA). The study aimed to determine the optimal initial dose, as previous research has shown low-dose oral minoxidil to be effective for AGA, but the best starting dose remains unclear. The trial is significant as it is the first head-to-head comparison of these specific doses in male AGA patients. The results of this study could provide valuable insights into the dose-dependent efficacy of oral minoxidil for hair regrowth in men with AGA.

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