Efficacy and Safety of Oral Dutasteride 0.5 mg Combined with Oral Minoxidil 2.5 mg for Male Androgenetic Alopecia: A Retrospective Cohort Study

    July 2026 in “ Research Square ”
    Hans Johnson, Daniel Reisel, Zaki Bandlish … David Huang

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

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    Research cited in this study 12

    1. Relative Efficacy of Conventional Monotherapies and Select Nonconventional, Over-The-Counter Products for Male Androgenetic Alopecia: A Network Meta-Analysis Study Journal of Cosmetic Dermatology · 2025
    2. Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients JAMA Dermatology · 2022
    3. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment Dermatology and therapy · 2020
    4. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    5. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    6. Superiority of Dutasteride Over Finasteride in Hair Regrowth and Reversal of Miniaturization in Men With Androgenetic Alopecia: A Randomized Controlled Open-Label, Evaluator-Blinded Study Indian Journal of Dermatology, Venereology and Leprology · 2016
    7. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    8. A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia Journal of The American Academy of Dermatology · 2014
    9. Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study Journal of The American Academy of Dermatology · 2010
    10. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    11. A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2002
    12. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998